Abnormalities of High Density Lipoproteins in Abetalipoproteinemia*
نویسندگان
چکیده
منابع مشابه
Abnormalities of high density lipoproteins in abetalipoproteinemia.
DETAILED STUDIES OF THE HIGH DENSITY LIPOPROTEINS FROM THREE PATIENTS WITH ABETALIPOPROTEINEMIA HAVE REVEALED THE FOLLOWING PRINCIPAL ABNORMALITIES: 1) High density lipoprotein 3 (HDL3) is reduced in both absolute and relative concentration, although HDL2 is present in normal amounts. 2) The phospholipid distribution of both HDL fractions is abnormal, with low concentrations of lecithin and an ...
متن کاملAbnormal high density lipoproteins of abetalipoproteinemia: relevance to normal HDL metabolism.
We investigated high density lipoprotein (HDL) subfractions in abetalipoproteinemia (ABL) using rate zonal ultracentrifugation. In ABL, HDL2 is the major subfraction, 65% of total mass compared to less than 10% in normal subjects with similar HDL levels. HDL2 and HDL3 in ABL (n = 3) are larger and lighter than in normals (n = 3), with mean diameters of 136 +/- 19 A and 100 +/- 12 A, respectivel...
متن کاملThe lipoproteins and lipid transport in abetalipoproteinemia.
The disease abetalipoproteinemia results in intriguing disturbances of lipid transport (2, 3). Included among its manifestations are an inability to form chylomicrons (4) and the lowest concentrations of plasma lipids detected in any human disorder. In this familial syndrome it is possible that the elaboration of beta lipoprotein, or more strictly its beta or B apoprotein, is primarily affected...
متن کامل[High-density lipoproteins].
the accurate mechanism of how EIIC transports a sugar has not been clearly demonstrated yet. To investigate more detailed and accurate transportation mechanisms, we performed collective variable-based steered molecular dynamics (CVSMD) simulations. Our simulation shows the spontaneous transportation of the sugar toward the opposite side of the membrane with the preserved H-bonding interactions,...
متن کاملMaturation of high-density lipoproteins.
Human high-density lipoproteins (HDLs) are involved in the transport of cholesterol. The mechanism by which HDL assembles and functions is not well understood owing to a lack of structural information on circulating spherical HDL. Here, we report a series of molecular dynamics simulations that describe the maturation of discoidal HDL into spherical HDL upon incorporation of cholesterol ester as...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1967
ISSN: 0021-9738
DOI: 10.1172/jci105608